As one of the most innovative restaurants in San Diego, we are committed to changing the way our guests think about food. Everything we do is made from scratch and with love, which is one of the many reasons we are referred to as Nature’s Kitchen. From our yeast-free signature breads to our fruit-infused sangrias, something is always cooking at Cafe 21.
Committed to sustainability and a true farm-to-table experience, we work with the best ingredients from locally grown produce, hormone-free grass fed meat, wild seafood, and antibiotic free Mary’s chicken. With an eclectic and unique menu offering, we accommodate all dietary restrictions ranging from gluten-free, vegetarian, and vegan. We like to say that it is always happy hour at Cafe 21. We’re serving up brunch, dinner and a complete line of craft cocktails every day of the week. With the best Happy Hour in downtown San Diego running daily from 3PM to 6PM to our nightly live local music, an unforgettable experience awaits you at Cafe 21!